Wahyudi Widada, Teddy Ontoseno, Bambang Purwanto



Hypercholesterolemia is a high level of cholesterol in the blood. Patients must take anti-cholesterol drugs for a long time, so they are at risk of experiencing side effects from the drug. Apo-B and total cholesterol are indicators of cholesterol levels in the blood. Wet cupping therapy is a method of excreting metabolic waste in the blood through the surface of the skin. The study aims to prove the effect of wet cupping therapy as a complementary therapy to decrease Apolipoprotein-B. Method: This research is Quasy experimental research using humans as research subjects. The dependent variable is Apo-B, and total cholesterol gave wet cupping treatment. Cupping is done twice, 7 points, using a G21 needle. A large sample of 32 people with hypercholesterolemia divided into treatment groups and control groups. The research subjects were selected based on sample inclusion criteria. After 12 hours of fasting and still taking simvastatin, blood was taken through 5ml of the brachial vein. Put into a 2ml purple tube containing EDTA the rest inserted in a red tube. Apo-B measurement using ELISA sandwich method, elabscience reagent, BiopharmaELISA reader tool, in units of ng/ml. Total cholesterol uses the enzymatic colorimetry method, diasys reagent, Biolyzer100 spectrophotometry, in mg/dl units. Data analysis was carried out with the Wilcoxon Signed Ranks Test with a significance level of 5% (α = 0.05), the pre-datacompared with the post data. Results: A significant reduction in Apo-B measurements with p-value 0.000 (α <0.05), SD 42. Conclusion: Intervention of wet cupping therapy can reduce Apo-B levels in the blood. Further research needs to be done to measure the potential for prevention of atherosclerosis.

Keywords: wet cupping, Apo-B, cholesterol, blood

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